The research group of Professor Hitoshi Masaki (Tokyo University of Technology) delivered a coveted oral presentation on the efficacy of AstaFusion™ at the 30th IFCSS Congress, themed “Cosmetics: Science for Beauty and Lifestyle”.
They described how the interference to reconstruction of the dermal matrix caused by extracellular carbonylated proteins through oxidative stress is reversed in normal human fibroblasts by treatment with AstaFusion™. The paper was entitled “Protein Oxidation Establishes a Loop of Intracellular Oxidation and Interferes with Reconstruction of the Dermal Matrix”. Authors areYumiko Yamawaki, Adelheid Kuehnle, Robert Schurr, Taeko Mizutani, Yuri Okano, and Hitoshi Masaki.
Carbonylated proteins (CPs) are oxidized proteins synthesized through the reactions of lipid peroxidation. CPs are observed in both epidermis and dermis of the skin chronically exposed to sunlight. CPs might be involved in the formation of the photoaged skin by promoting the degradation of the skin extracellular matrix (ECM) via stimulating the expression of MMP-1 and IL-8. Expression of both genes is detrimental to the skin matrix, as IL-8 proteins digest elastin fiber by recruiting neutrophils, and MMP-1 proteins digests collagen fiber. Normal human fibroblasts (NHDF) cultured with AstaFusion™ suppressed the accumulation of intracellular CP and down-regulated the mRNA expression of MMP-1 and IL-8 induced by model carbonylated protein treatment. AstaFusion™ is believed to be a useful material for preventing the progression of photoaged dermis due to the effect of extracellular CPs on dermal fibroblasts. It is expected to support the ECM through suppressing the degradation of elastin and collagen fibers.